INCREASED TUMOR NECROSIS FACTOR ALPHA (TNF-α) AND NATURAL KILLER CELL (NK) FUNCTION USING AN INTEGRATIVE APPROACH IN LATE STAGE CANCERS
Authors:
- Darryl SeeDSDarryl See
- Stephanie MasonSMStephanie Mason
- Ramesh RoshanRRRamesh Roshan
- 1 January 2002
- journal article
- Published by Taylor & Francis in Immunological Investigations
- Vol. 31 (2) , 137-153
Abstract
Natural products may increase cytotoxic activity of Natural Killer Cells (NK) Tumor Necrosis Factor alpha (TNF-α) while decreasing DNA damage in patients with late-stage cancer. Pilot studies have suggested that a combination of Nutraceuticals can raise NK cell function and TNF-α alpha activity and result in improved clinical outcomes in patients with late stage cancer. The objective of the study is to determine if Nutraceuticals can significantly raise NK function and TNF levels in patients with late stage cancer. After informed consent was obtained, 20 patients with stage IV, end-stage cancer were evaluated (one bladder, five breast, two prostate, one neuroblastoma, two non-small cell lung, three colon, 1 mesothelioma, two lymphoma, one ovarian, one gastric, one osteosarcoma). Transfer Factor Plus (TFP®, 3 tablets 3 times per day), IMUPlus® (non denatured milk whey protein, 40 gm/day); Intravenous (50 to 100 gm/day) and oral (1–2 gm/day) ascorbic acid; Agaricus Blazeii Murill teas (10 gm/day); Immune Mo...Keywords
This publication has 10 references indexed in Scilit:
- Cancer treatment by photodynamic therapy combined with adoptive immunotherapy using genetically altered natural killer cell lineInternational Journal of Cancer, 2001
- Isolation of an Antitumor Compound from Agaricus blazei Murill and Its Mechanism of ActionThe Journal of Nutrition, 2001
- Bone Metastasis Model With Multiorgan Dissemination of Human Small-Cell Lung Cancer (SBC-5) Cells in Natural Killer Cell-Depleted SCID MiceOncology Research, 2001
- Metal complexes of bovine lactoferrin inhibit in vitro replication of herpes simplex virus type 1 and 2BioMetals, 1998
- Selective tumoricidal effect of soluble proteoglucan extracted from the basidiomycete, Agaricus blazei Murill, mediated via natural killer cell activation and apoptosisCancer Immunology, Immunotherapy, 1998
- Retroviral vector-mediated transfer of the tumor necrosis factor alpha gene into human cancer cells restores an apoptotic cell death program and induces a bystander-killing effectBlood, 1996
- Activities and characteristics of transfer factorsBiotherapy, 1996
- Gene transfer of human TNFα into glioblastoma cells permits modulation of mdr1 expression and potentiation of chemosensitivityInternational Journal of Cancer, 1995
- Cell Differentiation-Inducing Diterpenes from Andrographis paniculata NEES.Chemical and Pharmaceutical Bulletin, 1994
- Cancer cachexiaAnti-Cancer Drugs, 1993