Regulatory roles of mast cells in immune responses
- 6 May 2016
- journal article
- review article
- Published by Springer Nature in Seminars in Immunopathology
- Vol. 38 (5) , 623-629
Abstract
Mast cells are important immune cells for host defense through activation of innate immunity (via toll-like receptors or complement receptors) and acquired immunity (via FcεRI). Conversely, mast cells also act as effector cells that exacerbate development of allergic or autoimmune disorders. Yet, several lines of evidence show that mast cells act as regulatory cells to suppress certain inflammatory diseases. Here, we review the mechanisms by which mast cells suppress diseases.Keywords
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