The climate change especially global warming may highly influence production performance of farm animals throughout the world. Global warming has a great impact on the production and reproductive activity of cattle and buffaloes. The Egyptian buffalo is an important tropical species adapted with the environmental and managerial conditions in Egypt and other developed countries. To at last ten years, Egypt exposed to waves of heat and cold which stressed the animals and decreased in animal production this was Cleary at year 2015. So we needed animals more tolerance to stressed (cold or heat) and can mead modifications to micro - environmental conditions around it, faster recovering from heat stress, little of water consumption and lower of methane emission. It is more necessary makes adaption for animal and mitigation for its with environmental conditions., to lees the bad effects to climatic change from environmental conditions on animals and from animals to environmental conditions for increased the animal production or maintain its. We can may be see the buffalo animal the best animals for makes adaption and mitigation for its. In that article we critically review the evidence supporting this belief and discuss same of its limitations. The Buffalo can be make changed its morphology and histology to maintain bioprocess, can acclimatization under any environmental conditions around its; its more adapted to hot conditions, and by supplementation diets tolerant cold weaves. With climatic change, we can increase milk and meat production from buffalo without drop in production or disruption on animals.