Serological Identification of Five HLA‐D Associated (Ia‐like) Determinants*

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Abstract
Five antisera raised within HLA‐A and ‐B compatible, HLA‐D disparate combinations were reactive in a modified NIH microcytotoxicity test with B lymphocytes, but not with T lymphocytes from the immunizing donor, as well as with B lymphocytes from most or all donors sharing his immunizing HLA‐D phenotype. Four antisera recognized structures closely associated with the HLA‐D determinants Dw2, Dw3, Dw4 and LD 108. One serum had a broad reactivity pattern including Dw3, Dw6 and some unknown specificity(ies). In population and family studies, these B lymphocyte antigens behaved as if they were governed by one genetic locus in the B‐D region of the HLA complex. We conclude that the antisera produced by this method recognize Ia‐like antigens identical to or very closely associated with the HLA‐D determinants.

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