Shape-based separation of micro-/nanoparticles in liquid phases

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Abstract
The production of particles with shape-specific properties is reliant upon the separation of micro-/nanoparticles of particular shapes from particle mixtures of similar volumes. However, compared to a large number of size-based particle separation methods, shape-based separation methods have not been adequately explored. We review various up-to-date approaches to shape-based separation of rigid micro-/nanoparticles in liquid phases including size exclusion chromatography, field flow fractionation, deterministic lateral displacement, inertial focusing, electrophoresis, magnetophoresis, self-assembly precipitation, and centrifugation. We discuss separation mechanisms by classifying them as either changes in surface interactions or extensions of size-based separation. The latter includes geometric restrictions and shape-dependent transport properties.
Funding Information
  • Center for Biomedical Research of Missouri S&T
  • Chemical and Biochemical Engineering Department of Missouri S&T
  • Intelligent Systems Center of Missouri S&T
  • Mechanical and Aerospace Engineering Department of Missouri S&T
  • National Institutes of Health

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