Data-Driven Modeling and Classification of Brain Blood-Flow Pathologies

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Abstract
Cerebral aneurysms and arteriovenous malformations are life-threatening hemodynamic pathologies of the brain. While surgical intervention is often essential to prevent fatal outcomes, it carries significant risks both during the procedure and in the postoperative period, making the management of these conditions highly challenging. Parameters of cerebral blood flow, routinely monitored during medical interventions or with modern noninvasive high-resolution imaging methods, could potentially be utilized in machine-learning-assisted protocols for risk assessment and therapeutic prognosis. To this end, we developed a linear oscillatory model of blood velocity and pressure for clinical data acquired from neurosurgical operations. Using the method of Sparse Identification of Nonlinear Dynamics (SINDy), the parameters of our model can be reconstructed online within milliseconds from a short time series of the hemodynamic variables. The identified parameter values enable automated classification of the blood-flow pathologies by means of logistic regression, achieving a balanced accuracy of 74%. Our results demonstrate the potential of this model for both diagnostic and prognostic applications, providing a robust and interpretable framework for assessing cerebral blood vessel conditions.
Funding Information
  • Lavrentyev Institute of Hydrodynamics (FWGG-2021-0009-2.3.1.2.10)
  • Sobolev Institute of Mathematics, Siberian Branch, Russian Academy of Sciences (FWNF-2024-0001)
  • PNRR MUR (PE0000023-NQSTI)
  • European Research Council (101039794)
  • Türkiye Bilimsel ve Teknolojik Araştırma Kurumu (118C236)
  • UK Research and Innovation (EP/Z002656/1)

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