CALCIUM DEPLETION OF SYNAPTOSOMES AFTER MORPHINE TREATMENT
Authors:
Open Access
- 1 August 1976
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 57 (4) , 521-526
Abstract
It was confirmed that morphine administration in vivo produced a selective decrease in the calcium content of synaptosomal fractions prepared from rat cerebral cortices. This effect was prevented by naloxone. After morphine or naloxone, there were no changes in the sodium, potassium and magnesium contents of any of the seven subcellular fractions tested. Since the selective calcium loss was found to occur from fractions similar to those reported to exhibit opiate receptor binding, it is concluded that calcium may play a role in the action of narcotic agonist drugs.Keywords
This publication has 18 references indexed in Scilit:
- MORPHINE INDUCED CALCIUM DEPLETION IN DISCRETE REGIONS OF RAT BRAIN1Journal of Neurochemistry, 1975
- Morphine and Ethanol: Selective Depletion of Regional Brain CalciumScience, 1974
- Effect of Na+ on Ca-Uptake of the synaptic plasma membraneLife Sciences, 1974
- Uptake of calcium ions by synaptosomes from rat brainBiochimica et Biophysica Acta (BBA) - Biomembranes, 1974
- Synaptic Macromolecules: Identification and MetabolismAnnual Review of Biochemistry, 1974
- Localization of opiate receptor binding in synaptic membranes of rat brainBrain Research, 1974
- ISOLATION AND PARTIAL CHARACTERIZATION OF RAT BRAIN SYNAPTIC PLASMA MEMBRANES1Journal of Neurochemistry, 1974
- SUBCELLULAR DISTRIBUTION OF POTASSIUM, SODIUM, MAGNESIUM, CALCIUM AND CHLORIDE IN CEREBRAL CORTEX1Journal of Neurochemistry, 1972
- MOVEMENTS OF CALCIUM AND OTHER CATIONS IN ISOLATED CEREBRAL TISSUES1Journal of Neurochemistry, 1971
- UPTAKE OF CALCIUM BY SUBCELLULAR FRACTIONS ISOLATED FROM OUABAIN‐TREATED CEREBRAL TISSUESJournal of Neurochemistry, 1969