The Utah Leukemia Case-Control Study

Authors:
  • JTJ. E. Till
    J. E. Till
  • RLR. D. Lloyd
    R. D. Lloyd
  • RKR. L. Kerber
    R. L. Kerber
  • DTD. C. Thomas
    D. C. Thomas
  • SPS. Preston-Martin
    S. Preston-Martin
  • JLJ. L. Lyon
    J. L. Lyon
  • WSW. Stevens
    W. Stevens
Publisher website
Google Scholar
Abstract
This paper discusses the dosimetry methodology used to estimate bone marrow dose and the results of dosimetry calculations for 6,507 subjects in an epidemiologic casecontrol study of leukemia among Utah residents. The estimated doses were used to determine if a higher incidence of leukemia among residents of Utah could have been attributed to exposure to radioactive fallout from above-ground nuclear weapons tests conducted at the Nevada Test Site. The objective of the dosimetry methodology was to estimate absorbed dose to active marrow specific to each case and each control subject. Data on the residence of each subject were available from records of the Church of Jesus Christ of Latter-day Saints. Deposition of fallout was determined from databases developed using historical measurements and exposure for each subject from each test was estimated using those data. Exposure was converted to dose by applying an age-dependent dose conversion factor and a factor for shielding. The median dose for all case and control subjects was 3.2 mGy. The maximum estimated mean dose for any case or control was 29 +/− 5.6 mGy (a resident of Washington County, UT). Uncertainties were estimated for each estimated dose. The results of the dosimetry calculations were applied in an epidemiological analysis.