An indicator of cancer: downregulation of Monoamine Oxidase-A in multiple organs and species
Open Access
- 1 January 2008
- journal article
- research article
- Published by Springer Nature in BMC Genomics
- Vol. 9 (1) , 134
Abstract
Identifying consistent changes in cellular function that occur in multiple types of cancer could revolutionize the way cancer is treated. Previous work has produced promising results such as the identification of p53. Recently drugs that affect serotonin reuptake were shown to reduce the risk of colon cancer in man. Here, we analyze an ensemble of cancer datasets focusing on genes involved in the serotonergic pathway. Genechip datasets consisting of cancerous tissue from human, mouse, rat, or zebrafish were extracted from the GEO database. We first compared gene expression between cancerous tissues and normal tissues for each type of cancer and then identified changes that were common to a variety of cancer types.Keywords
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