Evaluation of drug release from polymeric nanoparticles in simulated saliva and gastric media by asymmetric flow field–flow fractionation (AF4)
Open Access
- 3 September 2024
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in RSC Pharmaceutics
- Vol. 1 (5) , 994-1007
Abstract
Enrofloxacin release from PLGA nanocarriers was evaluated in simulated saliva and gastric fluid. AF4 and DFT analyses revealed that acidic solvent intrusion above Tg induced faster diffusive release, whereas media proteins had no significant effect.Keywords
Funding Information
- National Institute of Food and Agriculture (2018-67022-27969)
- U.S. Department of Agriculture
- National Institute of Standards and Technology (70NANB22H206)
- FMC Corporation (New Investigator Award)
- Ecolab
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