Divalent Cation Ionophores Stimulate Resorption and Inhibit DNA Synthesis in Cultured Fetal Rat Bone
Authors:
- 5 June 1981
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 212 (4499) , 1157-1159
Abstract
Two divalent cation ionophores, A23187 and Ionomycin, which are selective for calcium, stimulated the resorption of fetal rat long bones in organ culture at 0.1 to 1 micromolar but not at higher concentrations. Both agents inhibited DNA synthesis at concentrations that stimulated resorption. These results might explain the differences in ionophore effects on bone previously reported, and they imply that cell replication is not required for osteoclast formation in fetal rat long bone cultures.Keywords
This publication has 10 references indexed in Scilit:
- Effects of Parathyroid Hormone and Calcitonin on Osteoclast Formation in Vitro*Endocrinology, 1980
- In Vitro Effects of Ionophore A23187 on Skeletal Collagen and Noncollagen Protein Synthesis*Endocrinology, 1979
- Characterization of ionomycin as a calcium ionophore.Journal of Biological Chemistry, 1978
- The effect of A23187 upon calcium metabolism in the human lymphocyteBiochimica et Biophysica Acta (BBA) - Biomembranes, 1977
- The effect ofβ-blockade on ethanol-induced secretion of calcitonin in chronic renal failureCalcified Tissue International, 1976
- Bone resorption in organ culture: inhibition by the divalent cation ionophores A23187 and X-537A.Journal of Clinical Investigation, 1976
- Calcium and lymphocyte activationCellular Immunology, 1976
- Calcium Transport in Isolated Bone Cells III. Effects of Parathyroid Hormone and Cyclic 32,52-AMP1Endocrinology, 1975
- Parathyromimetic effects of the ionophore, A23187, on bone cells and organ culturesBiochemical and Biophysical Research Communications, 1975
- Bone Resorption in Tissue Culture. Factors Influencing the Response to Parathyroid Hormone *Journal of Clinical Investigation, 1965