Multispectroscopic DNA interaction and Docking studies
- 16 January 2018
- journal article
- research article
- Published by Wiley in Applied Organometallic Chemistry
- Vol. 32 (4)
Abstract
Two new water soluble oxovanadium(IV) complexes with formulae Na[VO(his)(met)SO4] (1) and Na[VO(gly)(met)SO4] (2), (gly=glycine his=histidine, and met=metformin) were synthesized and characterized by LCMS, UV‐Visible absorption, infrared spectra, magnetic moment, elemental analysis, thermal analysis and electronic spectral studies. The metal center was found in an octahedral geometry. DNA binding interaction of these complexes with CT DNA has been explored by UV‐Visible absorption, fluorescence, viscosity measurements and cleavage studies. Finally the binding of the complexes with CT‐DNA could be surface binding, mainly in the groove binding. The complexes were docked in to B‐DNA sequence, 5’(D*AP*CP*CP*GP*AP*CP*GP*TP*CP*GP*GP*T)‐3’ retrieved from protein data bank (PDB ID: 423D), using Discovery Studio 2.1 software.Keywords
This publication has 39 references indexed in Scilit:
- An Iron Complex of Dipyridophenazine as a Potent Photocytotoxic Agent in Visible LightInorganic Chemistry, 2009
- Synthesis and characterization of dinuclear macrocyclic cobalt(II), copper(II) and zinc(II) complexes derived from 2,2,2′,2′-S,S[bis(bis-N,N-2-thiobenzimidazolyloxalato-1,2-ethane)]: DNA binding and cleavage studiesEuropean Journal of Medicinal Chemistry, 2009
- Synthesis, Characterization, and DNA‐Binding Studies of Mononuclear Copper(II)–Phenanthroline–Tyrosine ComplexChemistry & Biodiversity, 2009
- Synthesis, characterisation and insulin-mimetic activity of oxovanadium(IV) complexes with amidrazone derivativesJournal of Inorganic Biochemistry, 2007
- Bactericidal activity of different oxovanadium(IV) complexes with Schiff bases and application of chelation theoryJournal of Enzyme Inhibition and Medicinal Chemistry, 2006
- Studies on the interaction of DNA and water‐soluble polymeric Schiff base–nickel complexesJournal of Applied Polymer Science, 2002
- Polycyclic aromatic hydrocarbons physically intercalate into duplex regions of denatured DNABiochemistry, 1987
- Selfassociation of daunomycinBiochemistry, 1982
- Quenching of fluorescence by oxygen. Probe for structural fluctuations in macromoleculesBiochemistry, 1973
- A Further Examination of the Molecular Weight and Size of Desoxypentose Nucleic AcidJournal of the American Chemical Society, 1954