Cytochrome P450 Gene-Based Drug Prescribing and Factors Impacting Translation into Routine Clinical Practice
Authors:
- 12 August 2005
- journal article
- Published by Taylor & Francis in Personalized Medicine
- Vol. 2 (3) , 213-224
Abstract
Pharmacogenetics represents a rapidly advancing, competitive field of investigation. Due to the potential for clinically recognizable interactions between a set of old polymorphic genes and a relatively new environmental insult (drugs), many human geneticists believe that variability in the drug-metabolizing enzyme systems will soon translate into clinical practice across entire populations. Despite this, the field has not yet received widespread clinical acceptance. This article will review the common cytochrome P450 gene polymorphisms and discuss the factors that may facilitate (or attenuate) their translation into clinical practice.Keywords
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