ClC-2 regulation of intestinal barrier function: Translation of basic science to therapeutic target
- 17 July 2015
- journal article
- review article
- Published by Taylor & Francis in Tissue Barriers
- Vol. 3 (4) , e1105906
Abstract
The ClC-2 chloride channel is a member of the voltage-gated chloride channel family. ClC-2 is involved in various physiological processes, including fluid transport and secretion, regulation of cell volume and pH, maintaining the membrane potential of the cell, cell-to-cell communication, and tissue homeostasis. Recently, our laboratory has accumulated evidence indicating a critical role of ClC-2 in the regulation of intestinal barrier function by altering inter-epithelial tight junction composition. This review will detail the role of ClC-2 in intestinal barrier function during intestinal disorders, including experimental ischemia/reperfusion injury and dextran sodium sulfate (DSS)-induced inflammatory bowel disease. Details of pharmacological manipulation of ClC-2 via prostone agonists will also be provided in an effort to show the potential therapeutic relevance of ClC-2 regulation, particularly during intestinal barrier disruption.Keywords
This publication has 129 references indexed in Scilit:
- Methadone but not Morphine Inhibits Lubiprostone-Stimulated Cl− Currents in T84 Intestinal Cells and Recombinant Human ClC-2, but not CFTR Cl− CurrentsCell Biochemistry and Biophysics, 2012
- Severe Defects in Absorptive Ion Transport in Distal Colons of Mice That Lack ClC-2 ChannelsGastroenterology, 2012
- Claudins: Control of Barrier Function and Regulation in Response to Oxidant StressAntioxidants & Redox Signaling, 2011
- Lubiprostone targets prostanoid EP4 receptors in ovine airwaysBritish Journal of Pharmacology, 2010
- Lubiprostone Stimulates Duodenal Bicarbonate Secretion in RatsDigestive Diseases and Sciences, 2009
- The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteriaProceedings of the National Academy of Sciences, 2008
- Activation of prostaglandin EP receptors by lubiprostone in rat and human stomach and colonBritish Journal of Pharmacology, 2008
- Toward a unifying model of malaria-induced channel activityProceedings of the National Academy of Sciences, 2007
- LIGHT Signals Directly to Intestinal Epithelia to Cause Barrier Dysfunction via Cytoskeletal and Endocytic MechanismsGastroenterology, 2007
- Chloride transporting capability of Calu‐3 epithelia following persistent knockdown of the cystic fibrosis transmembrane conductance regulator, CFTRBritish Journal of Pharmacology, 2007