Second harmonic generation microscopy analysis of extracellular matrix changes in human idiopathic pulmonary fibrosis

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Abstract
Idiopathic pulmonary fibrosis (IPF) is a chronic interstitial lung disease with unknown pathological etiology. It accounts for 34,000 deaths in the United States each year and the daily lives of thousands more are affected by its symptoms, including dyspnea, daily cough, limited exercise capacity, and fear of shortness of breath. Generally, the prognosis of IPF patients is poor in the aggregate with a median survival of three to four years postdiagnosis, whereas a lower percentage of patients (10 to 15%) live five or more years, highlighting the heterogeneity of disease progression.1,2 Prognosis is poor due to both the lack of effective therapeutic options and also due to limited knowledge of the disease pathology and underlying molecular and temporal changes associated with disease progression.
Funding Information
  • National Cancer Institute (R01 CA136590-01A1)
  • NIH National Cancer Institute (R01 CA136590-01A1)
  • K.T. acknowledges support under (5T32CA009206-34)
  • University of Wisconsin Institute for Clinical and Translation Research (1UL1RR025011)
  • University of Wisconsin Institute for Clinical and Translation Research (1UL1RR025011)
  • N.S. acknowledges support under (NIH 5K08HL093367)
  • Carbone Cancer Center Translational Science BioCore (NIH P30 CA014520)

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