SOD3 boosts T cell infiltration by normalizing the tumor endothelium and inducing laminin-α4
Authors:
Open Access
- 1 January 2020
- journal article
- other
- Published by Taylor & Francis in OncoImmunology
- Vol. 9 (1) , 1794163
Abstract
The conversion of a non-T cell-inflamed into a T cell-inflamed tumor microenvironment (TME) is a key to sensitizing tumors to T-cell-based immunotherapies. Recent data show that the extracellular s...Keywords
Funding Information
- Comunidad de Madrid (B2017/BMD-3733)
- Spanish Ministry of Science, Innovation and Universities, and the EU Social Fund (PRE2018-084023)
- Ministry of Economy and Competitiveness (SAF2017-83732-R)
This publication has 10 references indexed in Scilit:
- SOD3 induces a HIF-2α-dependent program in endothelial cells that provides a selective signal for tumor infiltration by T cellsJournal for ImmunoTherapy of Cancer, 2020
- Angiogenesis and immune checkpoint inhibitors as therapies for hepatocellular carcinoma: current knowledge and future research directionsJournal for ImmunoTherapy of Cancer, 2019
- T Cell–Inflamed versus Non-T Cell–Inflamed Tumors: A Conceptual Framework for Cancer Immunotherapy Drug Development and Combination Therapy SelectionCancer Immunology Research, 2018
- Genetic Mechanisms of Immune Evasion in Colorectal CancerCancer Discovery, 2018
- SOD3 improves the tumor response to chemotherapy by stabilizing endothelial HIF-2αNature Communications, 2018
- Extracellular superoxide dismutase and its role in cancerFree Radical Biology and Medicine, 2017
- Chemokine Receptor Signaling and the Hallmarks of Cancer2017
- Vascular laminins in physiology and pathologyMatrix Biology, 2017
- Heterozygous Deficiency of PHD2 Restores Tumor Oxygenation and Inhibits Metastasis via Endothelial NormalizationCell, 2009
- The Forkhead Box M1 Transcription Factor Is Essential for Embryonic Development of Pulmonary VasculatureJournal of Biological Chemistry, 2005