A mobile circular DNA element drives memory-related processes in mice
Authors:
- Haobin RenHRHaobin Ren
- Hao GongHGHao Gong
- Wei-Siang LiauWLWei-Siang Liau
- Qiongyi ZhaoQZQiongyi Zhao
- Alexander P. WalshAWAlexander P. Walsh
- Mason R.B. MusgroveMMMason R.B. Musgrove
- Joshua W.A. DaviesJDJoshua W.A. Davies
- Esmi L. ZajackowskiEZEsmi L. Zajackowski
- Sachithrani U. MadugalleSMSachithrani U. Madugalle
- Paul R. MarshallPMPaul R. Marshall
- Tian LanTLTian Lan
- Jichun ShiJSJichun Shi
Preprint
Abstract
Extrachromosomal circular DNAs (ecDNAs) are double stranded, closed loop DNA molecules that act independently of the genome. Here we report the discovery of a brain-enriched ecDNA, ecCldn34d , that regulates the transcriptional state of plasticity-related genes and is temporally associated with the stability of fear memories. ecDNA therefore represents a novel class of mobile DNA elements that are involved in experience-dependent neuroadaptation.Keywords
This publication has 19 references indexed in Scilit:
- Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorderNature Genetics, 2024
- Mapping catalytically engaged TOP2B in neurons reveals the principles of topoisomerase action within the genomeCell Reports, 2024
- ecDNA hubs drive cooperative intermolecular oncogene expressionNature, 2021
- Extrachromosomal DNA is associated with oncogene amplification and poor outcome across multiple cancersNature Genetics, 2020
- Dynamic regulation of Z-DNA in the mouse prefrontal cortex by the RNA-editing enzyme Adar1 is required for fear extinctionNature Neuroscience, 2020
- Circular ecDNA promotes accessible chromatin and high oncogene expressionNature, 2019
- NLGN1 and NLGN2 in the prefrontal cortex: their role in memory consolidation and strengtheningCurrent Opinion in Neurobiology, 2018
- Universal Real-Time PCR-Based Assay for Lentiviral TitrationMolecular Biotechnology, 2014
- Improved vectors and genome-wide libraries for CRISPR screeningNature Methods, 2014
- Prefrontal microcircuit underlies contextual learning after hippocampal lossProceedings of the National Academy of Sciences, 2013