Theoretical study of recycling in preparative chromatography

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Abstract
Using the equilibrium‐dispersive model of chromatography, we have investigated recycling as a means to improve the recovery yields and possibly the production rates of chromatographic separations. When compared with the optimal values obtained for the conventional single‐cycle regime, our results prove the potential for recycling in preparative chromatography. The analysis performed for the separation of two binary mixtures demonstrates that recycling not only improves the recovery yield but can increase the production rate under certain conditions. Different possibilities of collecting sufficiently separated fractions during recycling are compared. The mathematical model developed can be used effectively for designing optimal recycling strategies in preparative liquid chromatography.

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