Impact of MicroRNA in Normal and Pathological Respiratory Epithelia
Authors:
- Lisa Giovannini-ChamiLGLisa Giovannini-Chami
- Nathalie GrandvauxNGNathalie Grandvaux
- Laure-Emmanuelle ZaragosiLZLaure-Emmanuelle Zaragosi
- Karine Robbe-SermesantKRKarine Robbe-Sermesant
- Brice MarcetBMBrice Marcet
- Bruno CardinaudBCBruno Cardinaud
- Christelle CorauxCCChristelle Coraux
- Yves BerthiaumeYBYves Berthiaume
- Rainer WaldmannRWRainer Waldmann
- Bernard MariBMBernard Mari
- Pascal BarbryPBPascal Barbry
- 20 April 2011
- book chapter
- Published by Springer Nature
- Vol. 741, 171-191
Abstract
Extensive sequencing efforts, combined with ad hoc bioinformatics developments, have now led to the identification of 1222 distinct miRNAs in human (derived from 1368 distinct genomic loci) and of many miRNAs in other multicellular organisms. The present chapter is aimed at describing a general experimental strategy to identify specific miRNA expression profiles and to highlight the functional networks operating between them and their mRNA targets, including several miRNAs deregulated in cystic fibrosis and during differentiation of airway epithelial cells.Keywords
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