Speed of analgesic onset of two doses of ketoprofen lysine salt in tension-type headache

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Abstract
Aim. To compare the speed of onset, magnitude, and duration of the analgesic effect of two doses of ketoprofen lysine salt – 40 mg and 80 mg – for the acute treatment of tension-type headache in adults. Materials and methods. Thirty patients with episodic tension-type headache were enrolled in an open-label, prospective study and allocated to two groups of 15: KAP (ketoprofen lysine salt 80 mg) and KA (40 mg). Pain intensity (visual analogue scale, VAS) was assessed at baseline and 5, 10, 15, 30, 60, 120, and 240 minutes after intake; pain-reduction slope was also calculated. Quantitative data are presented as median and interquartile range (Me [Q1; Q3]); non-parametric methods were used. Differences were considered significant at p < 0.05. Results. Groups were comparable at baseline (VAS 8.0 [6.5; 8.5] and 7.0 [6.5; 8.0]). A significant reduction from baseline occurred by 10–15 minutes in both groups; a plateau was reached by 120 minutes, with median VAS approaching zero. Between-group differences in pain intensity and in the magnitude of reduction were not significant at any time point (p>0.20). Conclusion. Both doses provided fast (significant by 10–15 minutes) and sustained analgesia with good tolerability. No significant differences between the 40 mg and 80 mg doses were found in onset, magnitude, or duration. Given the comparable efficacy and the NSAID analgesic ceiling, either studied dose may be used; dose choice should be guided by clinical objectives and constraints (tolerability, comorbidities, adverse-event risk).

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