SP444IMPAIRED VASCULAR FUNCTION CONTRIBUTES TO EXERCISE INTOLERANCE IN CHRONIC KIDNEY DISEASE

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Abstract
Introduction and Aims: Exercise intolerance is an important feature in patients with CKD and an independent predictor of mortality. Limited data exist on underlying mechanisms in predialysis CKD. The contribution of vascular dysfunction, known to influence cardiovascular outcome in CKD, has not been studied before. The aim of this study was to gain more insight into the clinical (endothelial function and arterial stiffness), cellular (circulating vascular progenitor cells) and molecular (circulating microRNAs) determinants of exercise capacity in predialysis CKD.