Development of a High-Frequency Burst Pulse Generator for Cancer Cell Treatment and Comparison Between a High-Power Burst Pulse and a Single Pulse

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Abstract
Cancer treatment based on ultrashort pulses of strong electric fields has been developed as a novel biological application. This article focuses on the design of a compact high-power nanosecond pulsed electromagnetic wave generator for realizing cancer treatment via ultrashort pulsed electric fields. For this purpose, we developed a pulsed power generator that continuously outputs multiple pulses via a nonlinear transmission line (NLTL) using magnetic switches. The NLTL comprises a ladder of capacitors and saturable inductors and generates a pulse train by delaying the propagation of each pulse using the magnetic switch of each ladder. In this article, we achieved a higher output frequency compared to the previous generator. The frequency was increased from 13 to 150 MHz by employing a coaxial structure instead of discrete components. In addition, we demonstrate that the application of burst pulses to cancer cells is more effective than single pulses under the same conditions.
Funding Information
  • JSPS KAKENHI (JP26420220)

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