Efficient One Pot Synthesis of Phenylimidazo[1,2‐a]pyridine Derivatives using Multifunctional Copper Catalyst Supported on β‐Cyclodextrin Functionalized Magnetic Graphene oxide

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Abstract
In this paper, a novel, “green”, efficient and atom‐economical methodology for the synthesis of N‐(alkyl)‐2‐phenylimidazo[1,2‐a]pyridin‐3‐amine derivatives based on copper catalyzed oxidative cyclization is presented. An efficient copper nanocatalyst was fabricated by immobilization of Cu on β‐Cyclodextrin (βCD) functionalized magnetic graphene oxide nanosheets (denoted as Cu@βCD@MGO). This catalyst primarily oxidizes benzylic alcohols to aldehydes by aerobic O2. The obtained aldehydes, in situ, takes part in a three component reaction with pyridin‐2‐amine and isocyanides to produce corresponding N‐(alkyl)‐2‐phenylimidazo[1,2‐a]pyridin‐3‐amine derivatives. The catalyst was characterized by TEM, SEM, VSM, FT‐IR, XRD, TGA and ICP. As an advantage, the catalyst showed to be highly recoverable and no appreciable leaching was observed after 10 runs.

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