Results of a Pilot Trial Comparing Prolonged Intravenous Antibiotics With Sequential Intravenous/Oral Antibiotics for Children With Perforated Appendicitis

Authors:
  • RBRebecca L. Brown
    Rebecca L. Brown
  • GGGerald Gollin
    Gerald Gollin
  • MCMichael G. Caty
    Michael G. Caty
  • JGJames Gilbert
    James Gilbert
  • MSMichael A. Skinner
    Michael A. Skinner
  • PGPhilip L. Glick
    Philip L. Glick
  • RARichard G. Azizkhan
    Richard G. Azizkhan
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Abstract
PERFORATED appendicitis is a common condition in children that results in substantial morbidity and cost.1 Treatment for perforated appendicitis generally involves appendectomy followed by a course of broad-spectrum antibiotics. Antibiotic therapy, usually administered intravenously (IV), traditionally has involved agents directed at gram-negative and obligate anaerobic bacteria. Common drug regimens for perforated appendicitis in children include triple drug therapy (ampicillin, an aminoglycoside, and an antianaerobic agent), cephalosporins, carbapenems, or β-lactam/β-lactamase inhibitors.1