Akt and 14-3-3η regulate Miz1 to control cell-cycle arrest after DNA damage
- 5 December 2004
- journal article
- research article
- Published by Springer Nature in Nature Cell Biology
- Vol. 7 (1) , 30-41
Abstract
The transcription factor Miz1 is required for DNA-damage-induced cell-cycle arrest. We have now identified 14-3-3η as a gene that inhibits Miz1 function through interaction with its DNA binding domain. Binding of 14-3-3η to Miz1 depends on phosphorylation by Akt and regulates the recovery of cells from arrest after DNA damage. Miz1 has two functions in response to DNA damage: first, it is required for upregulation of a large group of genes, a function that is regulated by c-Myc, but not by 14-3-3η; second, Miz1 represses the expression of many genes in response to DNA damage in an Akt- and 14-3-3η-regulated manner.Keywords
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