Synthesis of Xenbucin using Suzuki reaction catalyzed by Pd/C in water
Authors:
Open Access
- 11 August 2008
- journal article
- Published by Walter de Gruyter GmbH in Open Chemistry
- Vol. 6 (3) , 390-392
Abstract
Xenbucin 1, an analgesic drug, was synthesized in 4 steps using two different routes. The biaryl fragment could successfully be produced via a Pd/C catalysed Suzuki coupling in water using sodium tetraphenylborate as a phenylation reagent. Overall yields of the routes were 36% and 59%, respectively.Keywords
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