Glutamatergic Receptor Trafficking and Delivery: Role of the Exocyst Complex

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Abstract
Cells comprise several intracellular membrane compartments that allow them to function properly. One of these functions is cargo movement, typically proteins and membranes within cells. These cargoes ride microtubules through vesicles from Golgi and recycling endosomes to the plasma membrane in order to be delivered and exocytosed. In neurons, synaptic functions employ this cargo trafficking to maintain inter-neuronal communication optimally. One of the complexes that oversee vesicle trafficking and tethering is the exocyst. The exocyst is a protein complex containing eight subunits first identified in yeast and then characterized in multicellular organisms. This complex is related to several cellular processes, including cellular growth, division, migration, and morphogenesis, among others. It has been associated with glutamatergic receptor trafficking and tethering into the synapse, providing the molecular machinery to deliver receptor-containing vesicles into the plasma membrane in a constitutive manner. In this review, we discuss the evidence so far published regarding receptor trafficking and the exocyst complex in both basal and stimulated levels, comparing constitutive trafficking and long-term potentiation-related trafficking.
Funding Information
  • Fondo Nacional de Desarrollo Científico y Tecnológico (1190620)
  • Comisión Nacional de Investigación Científica y Tecnológica (BMBF 20150065 (PCI))
  • Center for Excellence in Science and Technology (AFB 170005, PFB 12/2007)
  • Sociedad Química y Minera de Chile (Special grant “The role of lithium in human health and disease”)

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