An rfuABCD -Like Operon and Its Relationship to Riboflavin Utilization and Mammalian Infectivity by Borrelia burgdorferi
- 16 September 2021
- journal article
- research article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 89 (10) , IAI0030721
Abstract
Riboflavin is an essential micronutrient, but its transport and utilization have remained largely understudied among pathogenic spirochetes. Here, we show that Borrelia burgdorferi , the zoonotic spirochete that causes Lyme disease, is able to import riboflavin via products of its rfuABCD -like operon as well as synthesize flavin mononucleotide and flavin adenine dinucleotide despite lacking canonical genes for their synthesis.Keywords
Funding Information
- HHS | National Institutes of Health (AI-059062)
- HHS | National Institutes of Health (AI-056305)
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