The complete islet amyloid polypeptide precursor is encoded by two exons
Authors:
- J.W.M. HöppenerJHJ.W.M. Höppener
- C.J.M. LipsCLC.J.M. Lips
- H.S. JanszHJH.S. Jansz
- 10 April 1989
- journal article
- research article
- Published by Wiley in FEBS Letters
- Vol. 247 (1) , 154-158
Abstract
Islet amyloid polypeptide (IAPP) is the 37‐amino acid peptide subunit of amyloid found in pancreatic islets of type 2 diabetic patients and in insulinomas. Recently, we isolated the human gene encoding IAPP [(1988) FEBS Lett. 239, 227–232]. We now report the nucleotide sequences of a human insulinoma cDNA encoding a complete IAPP precursor, and of the corresponding parts of the IAPP gene. Two exons, which are approx. 5 kb apart in the human genome, encode the 89‐amino acid pre‐pro‐IAPP. At least one additional exon is present further upstream in the IAPP gene. A putative signal sequence at the amino‐terminus of the precursor suggests that IAPP is a secreted protein.Keywords
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