Impaired D2 receptor-dependent dopaminergic transmission in prefrontal cortex of awake mouse model of Parkinson’s disease
Authors:
- 26 August 2019
- journal article
- research article
- Published by Oxford University Press (OUP) in Brain
- Vol. 142 (10) , 3099-3115
Abstract
Anxiety is a major early-onset non-motor symptom in Parkinson’s disease, but the underlying mechanisms remain largely unknown. By imaging brain circuits in an awake parkinsonian mouse model, Li, Xu et al. provide evidence that Parkinson’s disease-associated anxiety is caused by impaired postsynaptic D2 receptor-dependent dopaminergic transmission in prefrontal cortex.Keywords
Funding Information
- National Key Research and Development Program of China (2016YFA0500401)
- National Natural Science Foundation of China (31761133016, 21790390, 31821091, 31330024, 31327901, 31400708, 31670843, 31600950, 21790394)
- National Basic Research Program of China (2012CB518006)
- Shaanxi Natural Science Funds for Distinguished Young Scholars of China (2019JC-07)
- Key Research and Development Program of Shaanxi province, China (2017SF-113)
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