Impaired human hippocampal neurogenesis after treatment for central nervous system malignancies
Authors:
- Michelle L. MonjeMichelle L. Monje
- Hannes VogelHVHannes Vogel
- Marilyn MasekMMMarilyn Masek
- Keith L. LigonKeith L. Ligon
- Paul G. FisherPaul G. Fisher
- Theo D. PalmerTheo D. Palmer
- 4 September 2007
- journal article
- research article
- Published by Wiley in Annals of Neurology
- Vol. 62 (5) , 515-520
Abstract
The effects of cancer treatments such as cranial radiation and chemotherapy on human hippocampal neurogenesis remain unknown. In this study, we examine neuropathological markers of neurogenesis and inflammation in the human hippocampus after treatment for acute myelogenous leukemia or medulloblastoma. We demonstrate a persistent radiation‐induced microglial inflammation that is accompanied by nearly complete inhibition of neurogenesis after cancer treatment. These findings are consistent with preclinical animal studies and suggest potential therapeutic strategies. Ann Neurol 2007Keywords
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