Sibling Recurrence Risk and Cross-aggregation of Attention-Deficit/Hyperactivity Disorder and Autism Spectrum Disorder
Authors:
Open Access
- 1 February 2019
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA Pediatrics
- Vol. 173 (2) , 147-152
Abstract
Attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) are 2 common and highly heritable1,2 neurodevelopmental disorders.3,4 Evidence of their shared heritability is mixed, with familial and twin studies suggesting an association,5-7 but molecular studies calling this into question.8 These disorders appear to share some genetic factors9 and biological pathways,10 although divergences in their neurobiological, cognitive, and genetic profiles are apparent.11-13 Although some findings may be accounted for by the co-occurrence of ADHD and ASD13 and others by heterogeneity within the 2 conditions,14 it remains unclear how related these disorders are etiologically. It is important to further characterize the degree of shared etiologic risk across these impairing, prevalent, and complex conditions.Keywords
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