Quantitative Evaluation of Liver Function with Use of Gadoxetate Disodium–enhanced MR Imaging
Authors:
- Akira YamadaAYAkira Yamada
- Takeshi HaraTHTakeshi Hara
- Feng LiFLFeng Li
- Yasunari FujinagaYFYasunari Fujinaga
- Kazuhiko UedaKUKazuhiko Ueda
- Masumi KadoyaMKMasumi Kadoya
- Kunio DoiKDKunio Doi
- 1 September 2011
- journal article
- Published by Radiological Society of North America (RSNA) in Radiology
- Vol. 260 (3) , 727-733
Abstract
Liver function correlating with plasma disappearance rate of indocyanine green can be estimated quantitatively from signal intensities and volumes of liver and spleen on contrast-enhanced MR images, improving estimation of the segmental liver reserve. PurposeTo determine whether liver function correlating with indocyanine green (ICG) clearance could be estimated quantitatively from gadoxetate disodium–enhanced magnetic resonance (MR) images.Materials and MethodsThis retrospective study was approved by the institutional review board, and the requirement for informed consent was waived. Twenty-three consecutive patients who underwent an ICG clearance test and gadoxetate disodium–enhanced MR imaging with the same parameters as were used for a preoperative examination were chosen. The hepatocellular uptake index (HUI) from liver volume (VL)and mean signal intensity of the liver on contrast-enhanced T1-weighted images with fat suppression (L20) and mean signal intensity of the spleen on contrast-enhanced T1-weighted images with fat suppression (S20) on 3D gradient-echo T1-weighted images with fat suppression obtained at 20 minutes after gadoxetate disodium (0.025 mmol per kilogram of body weight) administration was determined with the following equation: VL...Keywords
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