Study of the in Vitro Antiplasmodial, Antileishmanial and Antitrypanosomal Activities of Medicinal Plants from Saudi Arabia
Open Access
- 25 September 2012
- Vol. 17 (10) , 11379-11390
Abstract
The present study investigated the in vitro antiprotozoal activity of sixteen selected medicinal plants. Plant materials were extracted with methanol and screened in vitro against erythrocytic schizonts of Plasmodium falciparum, intracellular amastigotes of Leishmania infantum and Trypanosoma cruzi and free trypomastigotes of T. brucei. Cytotoxic activity was determined against MRC-5 cells to assess selectivity. The criterion for activity was an IC50 < 10 µg/mL (4. Antiplasmodial activity was found in the extracts of Prosopis juliflora and Punica granatum. Antileishmanial activity against L. infantum was demonstrated in Caralluma sinaica and Periploca aphylla. Amastigotes of T. cruzi were affected by the methanol extract of Albizia lebbeck pericarp, Caralluma sinaica, Periploca aphylla and Prosopius juliflora. Activity against T. brucei was obtained in Prosopis juliflora. Cytotoxicity (MRC-5 IC50 < 10 µg/mL) and hence non-specific activities were observed for Conocarpus lancifolius.Keywords
This publication has 47 references indexed in Scilit:
- In vitro antiplasmodial, antileishmanial and antitrypanosomal activities of selected medicinal plants used in the traditional Arabian Peninsular regionBMC Complementary and Alternative Medicine, 2012
- New Constituents from the Rhizomes of Egyptian Iris germanica L.Molecules, 2012
- Molecular Epidemiology and Spatial Distribution of a Waterborne Cryptosporidiosis Outbreak in AustraliaApplied and Environmental Microbiology, 2011
- Self-reported use of complementary and alternative medicine (CAM) products in topical treatment of diabetic foot disorders by diabetic patients in Jeddah, Western Saudi ArabiaBMC Research Notes, 2010
- Antiplasmodial Triterpenoids from the Fruits of Neem, Azadirachta indicaJournal of Natural Products, 2010
- Ellagitannins of the fruit rind of pomegranate (Punica granatum) antagonize in vitro the host inflammatory response mechanisms involved in the onset of malariaMalaria Journal, 2010
- In vitro and in vivo anti-malarial activity of Boerhavia elegans and Solanum surattenseMalaria Journal, 2010
- Antidiabetic effect of alcoholic extract of Caralluma sinaica L. on streptozotocin-induced diabetic rabbitsJournal of Ethnopharmacology, 2008
- Ethnomedicinal plant knowledge and practice of the Oromo ethnic group in southwestern EthiopiaJournal of Ethnobiology and Ethnomedicine, 2008
- The antiplasmodial activity of spermine alkaloids isolated from Albizia gummiferaFitoterapia, 2007