Design, synthesis and evaluation of 4-phenyl-1,2,3-triazole substituted pyrimidine derivatives as antiproliferative and tubulin polymerization inhibitors
Authors:
- Ashish Ranjan DwivediADAshish Ranjan Dwivedi
- Vijay KumarVKVijay Kumar
- Ravi Prakash YadavRYRavi Prakash Yadav
- Naveen KumarNKNaveen Kumar
- Kailash JangidKJKailash Jangid
- Piyush AnandPAPiyush Anand
- Deepak Kumar SharmaDSDeepak Kumar Sharma
- Somesh BarnawalSBSomesh Barnawal
- Vinod KumarVKVinod Kumar
- 25 June 2022
- journal article
- research article
- Published by Elsevier in Journal of Molecular Structure
- Vol. 1267
Abstract
No abstract availableKeywords
Funding Information
- Department of Science and Technology, Ministry of Science and Technology, India (EMR/2015/002339)
- Council of Scientific and Industrial Research, India (02/(0354)/19/EMRII)
This publication has 31 references indexed in Scilit:
- Synthesis and biological evaluation of salinomycin triazole analogues as anticancer agentsEuropean Journal of Medicinal Chemistry, 2017
- Preclinical Comparison of Osimertinib with Other EGFR-TKIs in EGFR-Mutant NSCLC Brain Metastases Models, and Early Evidence of Clinical Brain Metastases ActivityClinical Cancer Research, 2016
- Application of virtual screening to the discovery of novel nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with potential for the treatment of cancer and axonopathiesBioorganic & Medicinal Chemistry Letters, 2016
- Discovery of novel 1,2,3-triazole derivatives as anticancer agents using QSAR and in silico structural modificationSpringerPlus, 2015
- Cell death stages in single apoptotic and necrotic cells monitored by Raman microspectroscopyScientific Reports, 2014
- Synthesis and Biological Evaluation of 2,4,5-Substituted Pyrimidines as a New Class of Tubulin Polymerization InhibitorsJournal of Medicinal Chemistry, 2011
- Structure-based virtual screening of novel tubulin inhibitors and their characterization as anti-mitotic agentsBioorganic & Medicinal Chemistry, 2010
- Microtubules and resistance to tubulin-binding agentsNature Reviews Cancer, 2010
- Nilotinib for the treatment of chronic myeloid leukemia: An evidence-based reviewCore Evidence, 2009
- Microtubule-Destabilizing Agents: Structural and Mechanistic Insights from the Interaction of Colchicine and Vinblastine with Tubulin2008