Transition Metal Binding in DNA Solutions

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Abstract
Paramagnetic ions in water shorten the spin‐lattice relaxation time T1 of the water protons. The effectiveness with which the relaxation takes place depends not only on the ion concentration, but also on the environment of the paramagnetic ion. In some cases where the paramagnetic ion is bound to a large molecule such as DNA, it shortens the proton relaxation time to a greater extent than when it is in solution. By measuring T1 by a pulsed nuclear magnetic resonance method, we have studied the binding of transition metal ions to DNA. We have obtained estimates for the number of available binding sites as well as information on the type of site which the various ions are bound to.

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