Iron-Catalyzed Cross-Coupling of α-Allenyl Esters with Grignard Reagents for the Synthesis of 1,3-Dienes
Open Access
- 4 January 2023
- journal article
- research article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 25 (1) , 120-124
Abstract
Structurally diverse 1,3-dienes are valuable building blocks in organic synthesis. Herein we report the iron-catalyzed coupling between α-allenyl esters and Grignard reagents, which provides a fast and practical approach to a variety of complex substituted 1,3-dienes. The reaction involves an inexpensive iron catalyst, mild reaction conditions, and provides easy scale up.Keywords
Funding Information
- Vetenskapsr?det (2019-04042)
- Knut och Alice Wallenbergs Stiftelse (KAW 2016.0072)
- Stiftelsen Olle Engkvist Byggm?stare
- Stiftelsen f?r Milj?strategisk Forskning (2018/11)
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