Mexidol has been used in combination with basic therapy in 65 patients with mental disorders of organic genesis. The patients were treated during 56 days in accordance with a special scheme including the drug intake and intramuscular and intravenous injections. Mexidol exerted a positive effect on affective sphere, normalized the sleep-wake cycle, promoted rehabilitation of cognitive function thus improving the global clinical state of patients. Marked and significant improvement was found in 40,0% and 33,8% of cases, respectively. No severe side-effects were noticed.