Association between rice consumption and risk of cancer incidence in the California Teachers Study

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Abstract
Purpose We evaluated the contribution of rice intake, a source of dietary arsenic, to cancer risk in a population of women with likely low arsenic exposure from drinking water and variable rice intake who participated in the California Teachers Study. Methods Rice consumption was categorized into quartiles (< 9.6, 9.7–15.6, 15.7–42.7, and ≥ 42.8 g/day). Multivariable-adjusted hazard ratios and 95% confidence intervals (95% CI) for incident cancer were estimated comparing rice consumption categories with bladder, breast, kidney, lung, and pancreatic cancer, with progressive adjustment for age, total calories, BMI, race, smoking status, physical activity, and cancer-specific covariates. Results The number of breast, lung, pancreatic, bladder, and kidney cancer cases was 7,351; 1,100; 411; 344; and 238, respectively. The adjusted hazard ratios (95% CI) comparing the highest versus lowest rice intake quartiles were 1.07 (1.00–1.15); 0.87 (0.72–1.04); 0.95 (0.66–1.37); 1.11 (0.81–1.52) and 1.07 (0.72–1.59) for breast, lung, pancreatic, bladder, and kidney cancers, respectively. Results were consistent when rice was modeled as a continuous variable and in analyses stratified by smoking status. Conclusion Rice consumption was not associated with risk of kidney, lung or pancreatic cancer, except maybe a small excess risk for breast cancer and a small non-significant excess risk for bladder cancer, comparing the highest versus lowest quartile of rice intake. Due to lower consumption patterns in this cohort, future studies should involve populations for which rice is a staple food and use of an arsenic biomarker.
Funding Information
  • National Cancer Institute (U01-CA199277, P30-CA033572, P30-CA023100, UM1-CA164917, R01-CA077398)
  • National Institute of Environmental Health Sciences (P42-ES010349, P30-ES009089, R01-ES028758)

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