Synthesis of NG, NGDimethylarginine by Human Endothelial Cells
Authors:
- 1 January 1993
- journal article
- research article
- Published by Taylor & Francis in Endothelium
- Vol. 1 (3) , 137-140
Abstract
Endothelial cells synthesise nitric oxide from L-arginine and this process can be inhibited by NG, NG dimethylarginine (asymmetric dimethylarginine; ADMA), a constituent of plasma and urine. In the present study cultures of human umbilical vein endothelial cells have been shown to release ADMA. Over 7 days 5.1 ± 2.8; μg ADMA was produced by 107 cells (n = 8). These results suggest the presence of a metabolic pathway that may regulate NO synthesis within the endothelium.Keywords
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