Iridium-Catalyzed Asymmetric Allylic Substitution Reactions
Top Cited Papers
- 24 December 2018
- journal article
- review article
- Published by American Chemical Society (ACS) in Chemical Reviews
- Vol. 119 (3) , 1855-1969
Abstract
In this review, we summarize the origin and advancements of iridium-catalyzed asymmetric allylic substitution reactions during the past two decades. Since the first report in 1997, Ir-catalyzed asymmetric allylic substitution reactions have attracted intense attention due to their exceptionally high regio- and enantioselectivities. Ir-catalyzed asymmetric allylic substitution reactions have been significantly developed in recent years in many respects, including ligand development, mechanistic understanding, substrate scope, and application in the synthesis of complex functional molecules. In this review, an explicit outline of ligands, mechanism, scope of nucleophiles, and applications is presented.Keywords
Funding Information
- Ministry of Science and Technology of the People's Republic of China (2016YFA0202900)
- Science and Technology Commission of Shanghai Municipality (16XD1404300)
- National Natural Science Foundation of China (21332009, 21572252, 21821002)
- Chinese Academy of Sciences (QYZDYSSWSLH012, XDB20000000)
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