Pharmacokinetic study of a patient with diphenylhydantoin toxicity

Authors:
  • AAArthur J. Atkinson
    Arthur J. Atkinson
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Abstract
Sequential determinations of plasma diphenylhydantoin (DPH) concentration in a patient with DPH toxicity have been used to study its dose‐dependent elimination kinetics. A pharmacokinetic model has been proposed for DPH that provides estimates of the apparent distribution volume, and characterizes the elimination of this drug in terms of a maximal excretory rate and apparent Michaelis‐Menten constant. This three‐parameter model has been used to illustrate a retrospective way of evaluating some possible causes of DPH toxicity in this patient.