Postoperative radiotherapy in rectosigmoid cancer Dukes' B and C

Authors:
  • IBI Balslev
    I Balslev
  • MPM Pedersen
    M Pedersen
  • PTP S Teglbjaerg
    P S Teglbjaerg
  • FHF Hanberg-Sørensen
    F Hanberg-Sørensen
  • JBJ Bone
    J Bone
  • NJN O Jacobsen
    N O Jacobsen
  • JOJ Overgaard
    J Overgaard
  • ASA Sell
    A Sell
  • KBK Bertelsen
    K Bertelsen
  • EHE Hage
    E Hage
  • LHL Hansen
    L Hansen
  • OKO Kronborg
    O Kronborg
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Abstract
The design, and complications seen during the first 2 years, of a randomized trial of postoperative radiotherapy for rectosigmoid cancer Dukes' B and C are presented and discussed. It is concluded that the present complication rate—below 10% in 221 patients—permits continuation of the intake, which is planned to include 550 patients, to demonstrate a possible increase in crude 5-year survival by 15% (60-75% in Dukes' B and 25-40% in Dukes' C), on the basis of a 0·01 significance level and a probability that the experiment will be successful of 0·90.

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