Kv1.4 channel block by quinidine: evidence for a drug‐induced allosteric effect
Open Access
- 1 January 2003
- journal article
- research article
- Published by Wiley in The Journal of Physiology
- Vol. 546 (2) , 387-401
Abstract
We studied quinidine block of Kv1.4ΔN, a K+ channel lacking N-type inactivation, expressed in Xenopus ooctyes. Initially, quinidine intracellularly blocked the open channel so rapidly it overlapped w...Keywords
This publication has 49 references indexed in Scilit:
- Molecular basis of functional voltage‐gated K+ channel diversity in the mammalian myocardiumThe Journal of Physiology, 2000
- The Structure of the Potassium Channel: Molecular Basis of K + Conduction and SelectivityScience, 1998
- On the Mechanism by which 4-Aminopyridine Occludes Quinidine Block of the Cardiac K+ Channel, hKv1.5Journal of General Physiology, 1998
- Electrophysiological and pharmacological correspondence between Kv4.2 current and rat cardiac transient outward currentCardiovascular Research, 1997
- Dynamic Rearrangement of the Outer Mouth of a K+ Channel during GatingNeuron, 1996
- Use-Dependent Blockers and Exit Rate of the Last Ion from the Multi-Ion Pore of a K + ChannelScience, 1996
- Molecular determinants of voltage-dependent inactivation in calcium channelsNature, 1994
- Molecular Basis of Gating Charge Immobilization in Shaker Potassium ChannelsScience, 1991
- The inactivation gate of the Shaker K+ channel behaves like an open-channel blockerNeuron, 1991
- Two types of inactivation in Shaker K+ channels: Effects of alterations in the carboxy-terminal regionNeuron, 1991