Recent Advances in the Synthesis of Conformationally Locked Nucleosides and Their Success in Probing the Critical Question of Conformational Preferences by Their Biological Targets
Authors:
- Hyung R. MoonHMHyung R. Moon
- Yuichi YoshimuraYYYuichi Yoshimura
- Victor E. MarquezVMVictor E. Marquez
- 1 October 2003
- journal article
- review article
- Published by Taylor & Francis in Nucleosides, Nucleotides & Nucleic Acids
- Vol. 22 (5-8) , 547-557
Abstract
The present work describes some recent approaches to the syntheses of three classes of locked-North nucleosides: beta-D-ribo-, beta-D-deoxyribo-, and beta-D-dideoxyribonucleosides. The method developed for the latter class permitted access to a novel bicyclo[3.1.0]hexene-type nucleosides structurally similar to D4T and carbovir. A structural analysis and biological activities are discussed.Keywords
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