Cross-Reactivity of Phentermine with an Immunoassay Designed to Detect Amphetamine in a Meconium Specimen

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Abstract
Our laboratory uses ELISA reagents (Immunalysis) to detect drugs of abuse in meconium. Poor specificity of immunoassay reagents for amphetamines is well characterized and as a result, specimens that test positive for amphetamines by immunoassay are routinely tested by a second analytical method to prevent false-positive results. Our ELISA screen for meconium has separate detection antibodies for amphetamine and methamphetamine. The ELISA cutoff for these drugs is 20 ng/g. All positive screen results are confirmed by GC-MS.

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