Altered network efficiency in isolated REM sleep behavior disorder: A multicentric study

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Abstract
INTRODUCTION: Isolated rapid eye movement (REM) sleep behavior disorder (iRBD), characterized by abnormal movements during REM sleep, is a prodromal stage of dementia with Lewy bodies (DLB) and Parkinson's disease (PD). While iRBD shows emerging brain changes, their impact on structural connectivity and network efficiency, and their predictive value, remain poorly characterized.METHODS: In this international prospective study, 198 polysomnography‐confirmed iRBD patients and 174 controls underwent diffusion magnetic resonance imaging and were analyzed. Cutting‐edge diffusion tractography and network‐based statistics were applied to reconstruct individual connectomes and assess network properties predicting DLB or PD.RESULTS: Structural architecture was already disrupted in iRBD, with both reduced and compensatory increased connections. Global efficiency was decreased. Local efficiency in motor regions was altered and associated with early clinical symptoms. Altered local efficiency in the supramarginal gyrus predicted DLB only.DISCUSSION: Early disruption of brain architecture in iRBD predicts progression to synucleinopathy‐related dementia, offering a novel potential prognostic biomarker.Highlights: Isolated rapid eye movement sleep behavior disorder (iRBD) patients show significant alterations in inter‐regional structural connectivity. Global efficiency is reduced in iRBD compared to controls. Areas with increased local efficiency contribute to decreased global efficiency. Altered network efficiency is associated with emerging Parkinsonian features. Higher supramarginal efficiency predicts dementia with Lewy bodies in iRBD.
Funding Information
  • Agentura Pro Zdravotnický Výzkum České Republiky (NU21‐04‐00535)
  • Agence Nationale de la Recherche (ANR‐11‐INBS‐0006)
  • Michael J. Fox Foundation for Parkinson's Research
  • Parkinson Canada (2023‐0000000122)
  • Parkinson's UK (J‐2101)
  • Department of Health and Social Care
  • Fondation Thérèse et René Planiol
  • W. Garfield Weston Foundation
  • Parkinson Society Canada (PPG‐2023‐0000000122)

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