Genetic associations of surfactant protein D and angiotensin-converting enzyme with lung disease in preterm neonates
Open Access
- 29 September 2011
- journal article
- research article
- Published by Springer Nature in Journal of Perinatology
- Vol. 32 (5) , 349-355
Abstract
Objective: To replicate genetic associations with respiratory distress syndrome (RDS) and bronchopulmonary dysplasia (BPD) in genes related to surfactant deficiency, inflammation and infection, and the renin–angiotensin system. Study Design: We examined eight candidate genes for associations with RDS and BPD in 433 preterm birth (PTB—SFTPD) is associated with RDS in VPTB infants in that the T allele was overtransmitted from parents to offspring with RDS (P=8.4 × 10−3). We also observed the A allele of rs4351 in the angiotensin-converting enzyme (ACE) gene was overtransmitted from parents to VPTB offspring with BPD (P=9.8 × 10−3). Conclusion: These results give further insight into the genetic risk factors for complex neonatal respiratory diseases and provide more evidence of the importance of SFTPD and ACE in the etiology of RDS and BPD, respectively.Keywords
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