Transformation of Santonin to a Naproxen Analogue with Anti-Inflammatory Activity
- 24 May 2019
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 82 (6) , 1710-1713
Abstract
Santonin, a natural product, was aromatized with molecular iodine as the catalyst. The new compound was characterized as (S)-methyl-2-(7-hydroxy-5,8-dimethylnaphthalen-2-yl) propanoate (2) based on 2D NMR spectroscopic data. Structurally, compound 2 was highly similar to the anti-inflammatory drug naproxen. The new naproxen analogue had significant potency against cyclooxygenase 1 and 2 (IC50 = 31.0 and 66.1 μM, respectively).Keywords
Funding Information
- Council of Scientific and Industrial Research
- Indian Institute of Technology, Banaras Hindu University
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