Fabrication of RNA 3D Nanoprisms for Loading and Protection of Small RNAs and Model Drugs
Authors:
- 19 October 2016
- journal article
- research article
- Published by Wiley in Advanced Materials
- Vol. 28 (45) , 10079-10087
Abstract
Constructing containers with defined shape and size to load and protect therapeutics and subsequently control their release in the human body has long been a dream. The fabrication of 3D RNA prisms, characterized by atomic force microscopy, cryo‐electron microscopy, dynamic light scattering, and polyacrylamide gel electrophoresis, is reported for the loading and protection of small molecules, proteins, small RNA molecules, and their controlled release.Keywords
Funding Information
- National Institutes of Health (R01EB019036, U01CA151648)
- National Institutes of Health (P41GM103832, P50 GM103297)
- National Institutes of Health (P01GM091743)
- National Institutes of Health (P30CA177558)
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